세인트존스워트의 기전

  1. 신경전달물질 재흡수 억제: 세인트존스워트는 여러 신경전달물질의 재흡수를 억제합니다. 이는 세로토닌, 노르에피네프린, 도파민, GABA, 글루타메이트 등을 포함합니다 (Attention Required! | Cloudflare) (The Mechanism of Action of St. John's wort (Hypericum perforatum) in the Treatment of Depression) (ScienceDirect). 이러한 작용은 일반적인 항우울제와 유사합니다.

  2. 수용체 조절: 세인트존스워트 추출물은 쥐의 전두엽 피질에서 베타-아드레날린 수용체의 하향 조절(downregulation)과 세로토닌 5-HT2 수용체의 상향 조절(upregulation)을 유도합니다 (Butterweck Veronika) (Butterweck Veronika). 이는 우울증 치료에 중요한 역할을 할 수 있습니다.

  3. 하이퍼포린의 역할: 세인트존스워트의 주요 활성 성분인 하이퍼포린은 TRPC6 채널을 활성화시키는 것으로 알려져 있습니다 (El Hamdaoui Yamina). 또한 하이퍼포린은 PXR(NR1I2) 핵수용체를 활성화시켜 약물 상호작용을 유발할 수 있습니다.

  4. 항바이러스 및 항균 활성: 세인트존스워트는 in vitro 연구에서 항바이러스 및 항균 활성을 보입니다 (UpToDate). 이는 우울증 치료 외에도 다른 잠재적 용도가 있을 수 있음을 시사합니다.

  5. 신경계 영향: 세인트존스워트는 신경계에 긍정적인 영향을 미치는 신경 강장제로 작용할 수 있습니다 (Interactive Tools). 또한 경미한 진정 효과가 있어 기분을 안정시킬 수 있습니다.

  6. 항우울 효과: 세인트존스워트의 항우울 효과는 표준 항우울제와 유사한 방식으로 작용하여 뇌의 활동을 증가시키는 것으로 보입니다 (Just a moment...). 경증에서 중등도의 우울증 치료에 효과적일 수 있습니다 ( St. John's wort - Mayo Clinic) (Gurley Bill).

  7. 기타 효과: 세인트존스워트는 근육 이완제로도 작용하여 월경통을 완화하는 데 사용될 수 있습니다 (Interactive Tools).



References

(n.d.). Attention Required! | Cloudflare. Retrieved from https://go.drugbank.com/drugs/DB01892

(n.d.). The Mechanism of Action of St. John's wort (Hypericum perforatum) in the Treatment of Depression. Retrieved from https://www.ebmconsult.com/articles/herbal-supplement-st-john-wort-hypericum-perforatum-mechanism-depression

(n.d.). ScienceDirect. Retrieved from https://www.sciencedirect.com/science/article/abs/pii/S1043661802002669

Butterweck, V. (2003). Mechanism of Action of St John???s Wort in Depression. CNS Drugs. Springer Science and Business Media LLC. http://doi.org/10.2165/00023210-200317080-00001

Butterweck, V. (2003). Mechanism of Action of St John???s Wort in Depression. CNS Drugs. Springer Science and Business Media LLC. http://doi.org/10.2165/00023210-200317080-00001

El Hamdaoui, Y., Zheng, F., Fritz, N., Ye, L., Tran, M. A., Schwickert, K., … Friedland, K. (2022, October 12). Analysis of hyperforin (St. John’s wort) action at TRPC6 channel leads to the development of a new class of antidepressant drugs. Molecular Psychiatry. Springer Science and Business Media LLC. http://doi.org/10.1038/s41380-022-01804-3

(n.d.). UpToDate. Retrieved from https://www.uptodate.com/contents/clinical-use-of-st-johns-wort

(n.d.). Interactive Tools. Retrieved from https://www.urmc.rochester.edu/encyclopedia/content.aspx

Just a moment.. (n.d.). Just a moment.. Retrieved from https://www.mind.org.uk/information-support/drugs-and-treatments/complementary-and-alternative-therapies/st-john-s-wort/

St. John's wort - Mayo Clinic. (n.d.). St. John's wort - Mayo Clinic. Retrieved from https://www.mayoclinic.org/drugs-supplements-st-johns-wort/art-20362212

Gurley, B., Fifer, E., & Gardner, Z. (2012, May 7). Pharmacokinetic Herb-Drug Interactions (Part 2): Drug Interactions Involving Popular Botanical Dietary Supplements and Their Clinical Relevance. Planta Medica. Georg Thieme Verlag KG. http://doi.org/10.1055/s-0031-1298331

댓글

댓글 쓰기

이 블로그의 인기 게시물

Undyne from Undertale: Memorable Quotes Collection

Undyne is one of the most dynamic and inspirational characters in Undertale . As the head of the Royal Guard, her unwavering determination, courage, and passionate demeanor make her dialogues both impactful and memorable. Below is a curated collection of some of Undyne's most iconic lines from the game: 1. General Dialogue "If you got past ME, you can do ANYTHING! So don't worry! We're with you all the way!" Undyne encourages and supports the protagonist, showcasing her leadership and trust. 2. Battle Lines "I will KILL you." A fierce declaration during intense battles, emphasizing her determination. "En guarde!" A classic battle cry, drawing inspiration from fencing terminology. "As long as you're GREEN you CAN'T ESCAPE!" A mocking taunt aimed at opponents who are inexperienced. "Unless you learn to face danger head-on..." A challenge to adversaries to confront their fears and weaknesse...
자세한 내용 보기

Asgore Dreemurr from Undertale: Memorable Quotes Collection

Asgore Dreemurr from Undertale: Memorable Quotes Collection Asgore Dreemurr is a pivotal character in Undertale , serving as the king of the Underground and embodying themes of sacrifice, hope, and the complexities of leadership. His dialogue reflects his deep sense of responsibility, sorrow for past actions, and unwavering commitment to his kingdom's future. Below is a curated collection of Asgore's most impactful lines from the game: 1. General Dialogue "Oh... It is nice to meet you..." Asgore's gentle and sorrowful greeting, highlighting his compassionate nature despite his formidable presence. "I can never go back on my word..." A solemn declaration emphasizing his integrity and the weight of his promises. "I will restore hope to the Underground." Asgore's resolute statement of his mission to bring prosperity and peace to his kingdom. 2. Battle Lines "Seven human souls and King ASGORE will become a god. Six...
자세한 내용 보기

Gaster from Undertale: Memorable Quotes Collection

Gaster is one of the most enigmatic and mysterious characters in Undertale . Known as "The Man who Speaks in Hands," Gaster's presence is subtle, with much of his dialogue and lore being shrouded in secrecy and largely derived from fan theories and hidden game elements. Below is a curated collection of the most notable quotes and references associated with Gaster based on the provided search results: 1. Indirect and Cryptic References "Beware of the man who speaks in hands." , This ominous warning is issued by the River Person during one of their travels, cautioning the protagonist about the mysterious Gaster. "I think I may have discovered the lifeblood of monsters! If I can harness this properly, I may just be able to do the impossible!" A speculative statement attributed to Gaster, suggesting his relentless pursuit of knowledge and experimentation. Note that this quote appears to be from fan-made sources and is not confirmed as canon. ...
자세한 내용 보기